Modeling an extracellular environment for axonal pathfinding and fasciculation in the central nervous system

An increasing number of extracellular matrix molecules has been identified in the brain over the last couple of years. Various interactions have been identified between some of these molecules, indicating that they are components of an organized matrix. In this review, an attempt is made to arrive at a model for such a matrix, based on the current knowledge of the structure and interactions of these molecules.