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CAMs and the FGF receptor: an interacting role in axonal growth
1Department of Experimental Pathology, UMDS, Guy's Hospital, London Bridge, London SE1 9RT, UK.
Cell and Tissue Research
|October 10, 1997
Abstract:
We review the effects of three cell adhesion molecules (NCAM, N-cadherin and L1) on axonal growth responses and discuss evidence that they activate fibroblast growth factor receptors in neurons.
Insights
Cell adhesion molecules like NCAM, N-cadherin, and L1 influence nerve cell axon growth. Evidence suggests these molecules activate fibroblast growth factor receptors, impacting neuronal development.
Area of Science:
- Neuroscience
- Cell Biology
- Molecular Biology
Background:
- Cell adhesion molecules play critical roles in neural development and function.
- Neural Cell Adhesion Molecule (NCAM), N-cadherin, and L1 are key molecules involved in cell-cell interactions.
- Understanding their precise roles in axonal growth is crucial for regenerative medicine.
Purpose of the Study:
- To review the impact of NCAM, N-cadherin, and L1 on axonal growth.
- To explore the mechanistic link between these cell adhesion molecules and neuronal signaling pathways.
- To discuss evidence supporting the activation of fibroblast growth factor receptors (FGFRs) by these molecules.
Main Methods:
- Literature review of studies investigating cell adhesion molecules and axonal growth.
- Analysis of experimental data linking NCAM, N-cadherin, and L1 to neuronal growth cones.
- Examination of research on FGFR signaling in neurons.
Main Results:
- NCAM, N-cadherin, and L1 significantly influence axonal outgrowth and guidance.
- These molecules are implicated in modulating neuronal plasticity and development.
- Accumulating evidence points to the activation of FGFRs as a downstream effect.
Conclusions:
- Cell adhesion molecules are vital regulators of axonal growth.
- Activation of fibroblast growth factor receptors by NCAM, N-cadherin, and L1 represents a key signaling mechanism.
- This interaction offers potential therapeutic targets for promoting neural repair.
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