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Interleukin-6 is differently modulated by central opioid receptor subtypes
M Bertolucci1, C Perego, M G De Simoni
1Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
The American Journal of Physiology
|October 10, 1997
Summary
The brain
Area of Science:
- Neuroimmunology
- Endocrinology
Background:
- The endogenous opioid system modulates inflammatory responses.
- Interleukin-6 (IL-6) is a key cytokine in the acute phase response.
Purpose of the Study:
- To investigate the selective involvement of specific opioid receptor subtypes in modulating IL-6.
- To determine if opioid receptor blockade affects IL-6 induction by IL-1 beta.
Main Methods:
- Rats were pretreated with mu, delta, or kappa opioid receptor antagonists.
- Interleukin-1 beta (IL-1 beta) was administered centrally or peripherally.
- Serum IL-6 levels were measured 2 hours post-administration.
Main Results:
- Mu-receptor blockade enhanced IL-6 induction.
- Delta-receptor blockade decreased IL-6 induction.
- Antagonists affected central and peripheral IL-1 beta similarly.
Conclusions:
- Opioid modulation of the immune system involves a balance of opposing receptor effects.
- The brain's endogenous opioid system broadly regulates IL-6 levels.
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