Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Domain identification by clustering sequence alignments

X Guan1

  • 1Glaxo Wellcome Research and Development, Research Triangle Park, NC 27709, USA. xg42498@glaxowellcom.com

Proceedings. International Conference on Intelligent Systems for Molecular Biology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Standard establishment and standardized implementation of the NOSES type Ⅰ eversion technique for low rectal cancer].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

[Clinical investigation of in-stent restenosis following self-expanding intracranial artery stenting].

Zhonghua nei ke za zhi·2026
Same author

Clinicopathological features and prognosis of patients with colorectal Mucinous adenocarcinoma mixed with other pathological components: a nationwide retrospective study in China.

Techniques in coloproctology·2025
Same author

The BRAF<sup>V600E</sup> Mutation Enhances Age-Based Prognostic Stratification in Radioiodine-Treated Papillary Thyroid Cancer: A Retrospective Cohort Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

[Cross-lagged path analysis of the correlation between occupational stress and blood pressure in Xinjiang petroleum workers].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2025
Same author

Effective treatment of multiple oral mucoceles.

International journal of oral and maxillofacial surgery·2025
Same journal

Proceedings of the 8th International Conference on Intelligent Systems for Molecular Biology (ISMB 2000). San Diego, California, USA. August 19-23, 2000.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2001
Same journal

Analysis of gene expression data with pathway scores.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Towards a complete map of the protein space based on a unified sequence and structure analysis of all known proteins.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Mining for putative regulatory elements in the yeast genome using gene expression data.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

A multiple alignment algorithm for metabolic pathway analysis using enzyme hierarchy.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
Same journal

Sequence database search using jumping alignments.

Proceedings. International Conference on Intelligent Systems for Molecular Biology·2000
See all related articles

We developed a novel method to cluster sequence alignment data, making it easier to identify conserved domains from large sequence comparison searches. This approach enhances the exploration of biological sequence data.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Sequence databases are expanding rapidly, leading to large and complex results from sequence comparison tools like BLAST and FASTA.
  • Analyzing these extensive results to identify significant biological information, such as conserved domains, is challenging.

Purpose of the Study:

  • To present a new method for extracting domain information from sequence comparison search results.
  • To improve the efficiency and intuitiveness of exploring large-scale sequence alignment data.

Main Methods:

  • Clustering of alignment results based on similarity to the query sequence.
  • Utilizing efficient tree structures and algorithms for data organization.
  • Developing a flexible X-Window based interface for data exploration.

Related Experiment Videos

Main Results:

  • The method effectively organizes alignment data, facilitating the identification of structurally conserved elements.
  • Hierarchical data structures allow exploration at multiple levels, from main domains to distantly related features.
  • The interface provides an intuitive way to navigate and analyze complex sequence comparison outputs.

Conclusions:

  • The proposed method offers an efficient and intuitive approach to analyzing large sequence comparison results.
  • It aids in the discovery of domain information and evolutionary relationships within biological sequences.
  • This tool can significantly improve the process of biological data interpretation.