Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional MR imaging of the prefrontal cortex: specific activation in a working memory task

T Kammer1, M E Bellemann, F Gückel

  • 1Department of Psychiatry, University of Heidelberg, Germany.

Magnetic Resonance Imaging
|January 1, 1997
PubMed
Summary

This study used functional MRI to investigate brain activity during a working memory task. Results show significant activation in the dorsolateral prefrontal cortex for continuous context updating and active maintenance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of a piritramide based patient-controlled analgesia (PCA) as a standard of care for pain control in late abortion induction: A prospective cohort study from a patient perspective.

European journal of obstetrics & gynecology and reproductive biology: X·2023
Same author

A diagnostic support system based on pain drawings: binary and k-disease classification of EDS, GBS, FSHD, PROMM, and a control group with Pain2D.

Orphanet journal of rare diseases·2023
Same author

[Neuropsychological and MRI diagnostics in secondary progressive multiple sclerosis].

Der Nervenarzt·2021
Same author

[Scientific assessment and regulatory approval of radiological screening examinations in Germany].

Der Radiologe·2020
Same author

Nivolumab for treatment of progressive multifocal leukoencephalopathy in Sézary syndrome.

European journal of neurology·2020
Same author

Shedding light on the clinical recognition process of transient global amnesia.

European journal of neurology·2020

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Working memory is crucial for cognitive functions.
  • Identifying the neural correlates of working memory is an active area of research.
  • Functional magnetic resonance imaging (fMRI) is a key tool for mapping brain activity.

Purpose of the Study:

  • To identify cortical regions activated by a working memory task using fMRI.
  • To investigate the neural basis of continuous context updating and active maintenance.
  • To assess the applicability of the experimental paradigm in a clinical MRI setting.

Main Methods:

  • fMRI scans were performed on 16 healthy subjects using a 1.5-T magnet.
  • Subjects performed a letter detection task requiring working memory (activation) or a simple detection task (control).

Related Experiment Videos

  • Data analysis focused on anatomically defined regions-of-interest, with strategies to minimize movement artifacts.

    • Main Results:

    • Significant activation was observed in the dorsolateral prefrontal cortex (Brodmann's areas 9, 10, 46, 47) in both hemispheres.
    • The activation task and control condition differed only in task demand, not perceptual input or motor output.
    • The findings support previous research on non-lateralized prefrontal activation during working memory tasks.

    Conclusions:

    • The study successfully identified working memory-related activation in the dorsolateral prefrontal cortex.
    • The experimental paradigm is suitable for clinical fMRI applications.
    • Results corroborate existing evidence for bilateral dorsolateral prefrontal cortex engagement in continuous context updating and active maintenance.