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Study on cytotoxic oxygenated desmosterols isolated from the red alga Galaxaura marginata
J H Sheu1, S Y Huang, G H Wang
1Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan, Republic of China.
Journal of Natural Products
|October 10, 1997
Abstract:
Four novel oxygenated desmosterols, 24 zeta-hydroperoxy-6 beta-hydroxycholesta-4,25-dien-3-one (1), 25-hydroperoxy-6 beta-hydroxycholesta-4,23(E)-dien-3-one (2), 24 zeta-hydroperoxycholesta-4,25-diene-3,6-dione (3), and 25-hydroperoxycholesta-4,23(E)-diene-3,6-dione (4) were isolated from the marine red alga Galaxaura marginata. Steroids 1-4 and three synthetic oxygenated desmosterols 5-7 were shown to exhibit significant cytotoxicity against several cancer cell lines.