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Related Experiment Videos

Lobomycosis. An electronmicroscopic, histochemical and immunologic study

J Bhawan, R W Bain, D T Purtilo

    Journal of Cutaneous Pathology
    |January 1, 1976
    PubMed
    Summary

    Lobomycosis, a rare fungal infection, caused persistent facial lesions in a patient. The study found that host macrophages formed "Gaucher-like cells" due to an inability to digest the fungus.

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    Area of Science:

    • Mycology
    • Dermatology
    • Pathology

    Background:

    • Lobomycosis is a rare, chronic fungal infection affecting the skin.
    • The case involves a 73-year-old woman with long-standing nodular keloidal facial lesions.

    Observation:

    • Biopsy revealed numerous fungal elements within giant cells and macrophages.
    • Macrophages exhibited abundant pink cytoplasm, resembling
    • Gaucher-like cells
    • under electron microscopy.
    • A transition from organism-containing macrophages to these Gaucher-like cells was observed.

    Findings:

    • The fungal cells were identified within host macrophages.
    • Macrophages appeared morphologically similar to Gaucher cells, rich in glycoproteins.

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  • Immunological studies confirmed the presence of antibodies against the fungus in the patient's serum.

    • Implications:

    • The formation of Gaucher-like cells is hypothesized to result from a host macrophage defect in degrading fungal glycoprotein capsules.
    • This finding offers insight into the pathophysiology of lobomycosis.
    • Further research may elucidate host-pathogen interactions in this rare fungal infection.