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Related Experiment Videos

Cobalamin, the stomach, and aging

R Carmel1

  • 1Department of Medicine, New York Methodist Hospital, Brooklyn 11215, USA. rcarmel@pol.net

The American Journal of Clinical Nutrition
|October 10, 1997
PubMed
Summary
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Mild cobalamin deficiency is common in older adults and not a normal part of aging. Food-cobalamin malabsorption is a frequent cause, highlighting the need for better management strategies.

Area of Science:

  • Gerontology
  • Nutritional Science
  • Internal Medicine

Background:

  • Low cobalamin (vitamin B12) levels are prevalent in the elderly population.
  • Cellular cobalamin deficiency is evident in most elderly individuals, even without overt symptoms.
  • This deficiency is not a natural aging process but an increased risk in older adults.

Purpose of the Study:

  • To investigate the prevalence and causes of cobalamin deficiency in the elderly.
  • To differentiate between normal aging and pathological deficiency states.
  • To inform management strategies for preclinical cobalamin deficiency.

Main Methods:

  • Review of existing literature on cobalamin metabolism and deficiency in aging.
  • Analysis of metabolic data indicating cellular cobalamin status.

Related Experiment Videos

  • Comparison of deficiency causes, including pernicious anemia and food-cobalamin malabsorption.

    • Main Results:

    • Food-cobalamin malabsorption, often linked to atrophic gastritis, is more common than pernicious anemia in causing deficiency.
    • Partial malabsorption leads to slower cobalamin depletion, explaining preclinical deficiency prevalence.
    • Elderly individuals are at higher risk for mild, preclinical cobalamin deficiency.

    Conclusions:

    • Cobalamin deficiency in the elderly is a significant issue requiring further research.
    • Management decisions are complicated by various factors, including potential iatrogenic or dietary influences.
    • Understanding the mechanisms of food-cobalamin malabsorption is crucial for effective intervention.