Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Comparative effect of PGE2 and PGI2 on renal function

E Villa1, R Garcia-Robles, J Haas

  • 1Hospital Ramón y Cajal, Madrid, Spain.

Hypertension (Dallas, Tex. : 1979)
|October 10, 1997
PubMed
Summary

Prostaglandin E2 (PGE2) increases sodium excretion and renal blood flow, while its stable analogue, iloprost (a prostacyclin, PGI2), shows a blunted natriuretic effect and no hemodynamic impact in anesthetized dogs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictors of acute lymphopenia after radiotherapy for prostate cancer including pelvic node irradiation: results of a real-world prospective multi-centric study.

ESMO real world data and digital oncology·2026
Same author

Results from the T2K Experiment on Neutrino Mixing Including a New Far Detector μ-like Sample.

Physical review letters·2026
Same author

First Differential Measurement of the Single π^{+} Production Cross Section in Neutrino Neutral-Current Scattering.

Physical review letters·2025
Same author

First Measurement of the Electron-Neutrino Charged-Current Pion Production Cross Section on Carbon with the T2K Near Detector.

Physical review letters·2025
Same author

First Joint Oscillation Analysis of Super-Kamiokande Atmospheric and T2K Accelerator Neutrino Data.

Physical review letters·2025
Same author

Measurements of neutrino oscillation parameters from the T2K experiment using <math><mrow><mn>3.6</mn><mo>×</mo><msup><mn>10</mn><mn>21</mn></msup></mrow></math> protons on target.

The European physical journal. C, Particles and fields·2023

Area of Science:

  • Nephrology
  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Prostacyclin (PGI2) is rapidly degraded, limiting studies on its natriuretic effects.
  • Stable PGI2 analogues like iloprost enable comparative research with other prostaglandins.
  • Prostaglandin E2 (PGE2) is known to influence renal function.

Purpose of the Study:

  • To compare the intrarenal effects of PGE2 and iloprost on renal hemodynamics and sodium excretion.
  • To investigate the natriuretic and vasodilator responses to stable PGI2 analogue iloprost versus PGE2.
  • To determine if PGE2-induced natriuresis is linked to increased renal blood flow.

Main Methods:

  • Six anesthetized dogs were administered two doses (1 and 4 ng/kg/min) of PGE2 and iloprost sequentially.
  • Renal blood flow (RBF), glomerular filtration rate (GFR), and fractional sodium excretion (FENa) were measured.
  • A washout period was implemented between the administration of PGE2 and iloprost.

Main Results:

  • PGE2 significantly increased FENa and RBF at both doses, without altering mean arterial pressure or GFR.
  • Iloprost, at identical doses, did not affect RBF or GFR, and only produced a significant natriuresis at the highest dose.
  • PGE2 demonstrated a dose-dependent natriuretic and vasodilatory effect, whereas iloprost's natriuretic effect was markedly blunted.

Conclusions:

  • PGE2 exerts a significant natriuretic effect associated with increased renal blood flow.
  • PGI2 (iloprost) exhibits minimal hemodynamic effects and a blunted natriuretic response compared to PGE2.
  • The stability of iloprost allows for direct comparison, highlighting differential renal actions of prostaglandins.

Related Experiment Videos