Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ATP synthase: a tentative structural model

S Engelbrecht1, W Junge

  • 1Universität Osnabrück, AG Biophysik, Germany. engel@uni-osnabrueck.de

FEBS Letters
|October 10, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating risk probabilities for sickness from behavioural patterns to identify health challenges in dairy cows with multivariate cumulative sum control charts.

Animal : an international journal of animal bioscience·2022
Same author

Variable selection for monitoring sickness behavior in lactating dairy cattle with the application of control charts.

Journal of dairy science·2021
Same author

Estimation of genetic parameters and breeding values for feed intake and energy balance using pedigree relationships or single-step genomic evaluation in Holstein Friesian cows.

Journal of dairy science·2019
Same author

Lactation curves and model evaluation for feed intake and energy balance in dairy cows.

Journal of dairy science·2019
Same author

Day or overnight transfusion in critically ill patients: does it matter?

Vox sanguinis·2018
Same author

Developing a multi-Kinect-system for monitoring in dairy cows: object recognition and surface analysis using wavelets.

Animal : an international journal of animal bioscience·2016

Adenosine triphosphate (ATP) synthase, nature's smallest rotary engine, converts electrochemical energy into chemical energy. This review proposes a structural model for the complete ATP synthase enzyme, aiding future research.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Adenosine triphosphate (ATP) synthase is a molecular machine essential for life, producing ATP from ADP and inorganic phosphate.
  • It harnesses proton- or sodium-motive force across membranes in all domains of life (Archaea, Bacteria, Eucarya).
  • The enzyme's function relies on the mechanical coupling of its membrane-bound (Fo) and catalytic headpiece (F1) portions via rotating subunits.

Purpose of the Study:

  • To review available structural data of ATP synthase.
  • To construct a tentative topological model of the holoenzyme.
  • To provide a heuristic model for ongoing studies on this enzyme.

Main Methods:

  • Review of published structural data for ATP synthase subunits.

Related Experiment Videos

  • Integration of partial structures and available 3D structures.
  • Development of a tentative topological model for the holoenzyme.

    • Main Results:

    • Partial structures of at least six ATP synthase subunits are known.
    • A 3-dimensional structure exists for the F1 assembly (α3β3)γ.
    • A proposed model identifies the rotor (c, ε, γ) and stator (a, b2, δ, (α3β3)γ) components.

    Conclusions:

    • The proposed model offers a tentative topological structure of the ATP synthase holoenzyme.
    • The model integrates known structural data and proposes subunit arrangements for the rotor and stator.
    • This model may serve as a valuable tool for future research into ATP synthase mechanisms.