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Lack of association between schizophrenia and a polymorphism close to the cytosolic phospholipase A2 gene
1Department of Molecular & Cell Biology, University of Aberdeen Medical School, UK.
Psychiatric Genetics
|November 5, 1997
Abstract:
Biochemical studies have shown that a proportion of schizophrenics have an abnormal fatty acid composition in their red blood-cell membrane phospholipids and it has been suggested that this might be due to altered levels of the enzyme phospholipase A2 (PLA2). A recent report indicated that there was an association between schizophrenia and alleles of a poly-A repeat polymorphism close to the 5' end of the PLA2 gene. We report the analysis of this polymorphism in a series of 58 schizophrenic patients and 56 controls and find no evidence for allelic association.