Influence of membrane oxygenators on the pulsatile flow in extracorporeal circuits: an experimental analysis

An experimental analysis was carried out to evaluate the effects induced by two typical extracorporeal circuits on the pressure and flow generated by a roller pump with a pulsatile module. The hydraulic behaviour of the patient was simulated by means of a mechanical mock-up system consisting of a few lumped parameters reproducing the physiologic vascular impedance. Pressure and flow tracings were acquired at different locations along the circuit using an automatic data acquisition system. Nine lest conditions with different pulse frequency and systolic time values were examined using a mean volumetric flow rate of approximately 4 l/min. A complete analysis of the results obtained in terms of pressure drops and inflow-outflow differences across the components of the arterial line, as well as the calculation of the hydraulic pulsatile power along the circuit, allowed us to assess the influence of the various components upon the pulsatility. The results indicated that the membrane oxygenators tested slightly affect the pulsatility of the flow and the pressure; on the contrary the arterial pipe line is responsible for large damping and head losses. To optimize the use of pulsatile flow for cardiopulmonary bypass it is necessary to reduce the length of the arterial pipe lines thus integrating the circuit as much as possible.