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Related Experiment Videos

Atypical urinary opiate excretion pattern

L R Glass1, S T Ingalls, C L Schilling

  • 1Research Service, Department of Veterans Affairs Medical Center, Brecksville, Ohio 44141, USA.

Journal of Analytical Toxicology
|November 5, 1997
PubMed
Summary
This summary is machine-generated.

Heroin abuse is typically indicated by 6-acetylmorphine (6-AM) in urine. However, identical twins showed unusual opiate metabolism, with high 6-AM levels and low morphine, challenging standard drug testing interpretation.

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Area of Science:

  • Forensic Toxicology
  • Pharmacokinetics
  • Metabolism Studies

Background:

  • Heroin (diacetylmorphine) is rapidly hydrolyzed to 6-acetylmorphine (6-AM) and then to morphine.
  • Urinary 6-AM is a key biomarker for heroin use, but typically found at low concentrations relative to total morphine (MOR).
  • Atypical opiate metabolism can complicate drug testing interpretation.