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Comparison of Helicobacter pylori antibody levels in children in Riyadh

A M Abdullah1, M O Gad el Rab, I al Ayed

  • 1Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|April 1, 1997
PubMed

Insights

Helicobacter pylori (H. pylori) antibody testing in Saudi children revealed significant differences between symptomatic and asymptomatic groups. ELISA is a valuable screening tool for diagnosing H. pylori infection in pediatric populations.

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Gastroenterology

Background:

  • Helicobacter pylori (H. pylori) infection is a global health concern, particularly in children.
  • Understanding the prevalence and diagnostic methods for H. pylori in pediatric populations is crucial.

Purpose of the Study:

  • To determine the levels of Helicobacter pylori (H. pylori) specific IgG and IgA antibodies in asymptomatic and symptomatic children in Saudi Arabia.
  • To evaluate the efficacy of ELISA as a screening test for H. pylori infection in children.

Main Methods:

  • Blood samples were collected from 229 asymptomatic and 43 symptomatic children.
  • Enzyme-Linked Immunosorbent Assay (ELISA) was used to detect H. pylori specific IgG and IgA antibodies.
  • Statistical analysis was performed to compare antibody levels between groups.

Main Results:

  • A statistically significant difference (p = 0.00001) in both IgG and IgA antibody levels was observed between asymptomatic and symptomatic children.
  • These findings indicate a higher prevalence or stronger immune response to H. pylori in symptomatic children.

Conclusions:

  • Helicobacter pylori antibody determination using ELISA is a reliable and effective screening method for diagnosing H. pylori infection in children.
  • The study highlights the utility of serological testing for pediatric H. pylori screening in Saudi Arabia.

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