Related Experiment Video
Updated: Oct 2, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Effect of duodenal acidification on gastric mucus and acid secretion in conscious cats
Abstract:
In cats with gastric fistulae and Heidenhein pouches, the effect of acid entering the duodenum on secretion of acid, pepsin, and mucus from the Heidenhain pouch during maximal acid stimulation with pentagastrin or histamine, was studied. Duodenal acidification produced stimulation of pepsin and mucus secretion comparable to that induced by exogenous hormones (secretin and the combination of secretin with cholecystokinin). In addition, duodenal acidification caused an increase in acid secretion, thus suggesting that, in addition to secretin and cholecystokinin, a factor that stimulates acid secretion was also released by acid.
Related Concept Videos
Stomach pH Regulation
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
Composition of Polyprotic Acid Solutions as a Function of pH
A graph with the alpha values is plotted against the volume of base added during titration. Here, a...
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...
Peptic Ulcer
Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease II: Pathophysiology

