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Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
A Rehemtulla1, C A Hamilton, A M Chinnaiyan
1Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.
The Journal of Biological Chemistry
|November 5, 1997
Abstract:
Exposure to ultraviolet light (UV) can induce apoptosis in mammalian cells. The mechanism by which UV radiation engages the suicide apparatus is unclear. Here we demonstrate that UV radiation can activate the Fas pathway via receptor aggregation and subsequent recruitment of the death adaptor molecule FADD/MORT1. UV radiation-induced apoptosis was inhibited by both a dominant negative version of FADD (FADD-DN) and the caspase inhibitor CrmA. Thus, activation of the Fas pathway represents a physiologic mechanism by which UV-damaged cells are eliminated.