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Updated: Aug 6, 2026
In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines
Published on: March 5, 2019
Immunogenetic and oncogenic properties of rat trophoblast cell lines
H W Kunz1, X J Yuan, S K Salgar
1Department of Pathology, University of Pittsburgh School of Medicine, PA 15261, USA.
Problem:
The nature of major histocompatibility complex (MHC) antigen expression on rat placentas, trophoblast cell lines, and tumors derived from trophoblast cells was explored.
Method Of Study:
Cytohistochemical and flow cytometric analysis and molecular techniques.
Results:
MHC antigen expression and genomic imprinting on the placenta and on trophoblast cells varies with the time of gestation and with the type of MHC antigen.
Conclusions:
There is no correlation in trophoblast cells between class I expression and cell ploidy, on the one hand, and malignant potential, on the other hand. Genomic imprinting of class I antigens in the rat placenta is a quantitative phenomenon.
