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Published on: October 21, 2015
Expression of TJ6 during pregnancy
J A Kang1, B A McBey, V Angkachatchai
1Department of Microbiology and Immunology, Finch University of Health Sciences, Chicago Medical School, IL 60064, USA.
Problem:
TJ6 will be one of the molecules involved in fetal-specific immune suppression during pregnancy. In the mouse and human decidua, the regulation of uterine natural killer (uNK) cells is important during pregnancy.
Method Of Study:
To further understand the possible functions of TJ6 during pregnancy, syngeneic, allogeneic, and mutant mice were examined for TJ6 expression.
Results:
Immunoblotting showed that TJ6 protein was expressed on most of the placenta-associated mononuclear cells, and the size was 70-72 kDa at all stages of pregnancy. The expression of TJ6 mRNA was studied by a ribonuclease protection assay in syngeneic and allogeneic matings, and in immune-deficient mice of genotypes scid/scid and scid/scid.bg/bg.
Conclusions:
Genetic disparity, lack of T and B lymphocytes, and loss of NK lytic function had no significant effect on the expression of TJ6 mRNA.
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