Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serologic allogeneic chimerism

J C McDonald1, I Adamashvili, G B Zibari

  • 1Department of Surgery, Louisiana State University Medical Center, Shreveport 71130, USA.

Transplantation
|October 27, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Portal-endocrine and gastric-exocrine drainage technique in pancreatic transplantation.

International journal of organ transplantation medicine·2014
Same author

Immunological response of sheep to injections of plasmids encoding Toxoplasma gondii SAG1 and ROP1 genes.

Parasite immunology·2010
Same author

Role of FDG-PET in the evaluation and staging of hepatocellular carcinoma with comparison of tumor size, AFP level, and histologic grade.

International surgery·2010
Same author

Post transplant lymphocele: a single centre experience.

Clinical transplantation·2004
Same author

21st century personal dosimetry?

Radiation protection dosimetry·2003
Same author

When will east meet west?

Radiation protection dosimetry·2003
Same journal

Preformed Anti-DQ Alpha Donor-specific Antibodies and the Risk of Antibody-mediated Rejection After Kidney Transplantation.

Transplantation·2026
Same journal

People in Transplantation: Professor Nadey Hakim, MD, PhD, FRCS, FRCSGlas (Hon), FACS, President-Elect of The Transplantation Society.

Transplantation·2026
Same journal

IL-1 Receptor Blockade Modulates Inflammation During Sequential Perfusion in Ex Vivo Porcine Kidneys.

Transplantation·2026
Same journal

Regulatory T Cells Allosensitized Under the Blockade of CD80/CD86-CD28 Costimulation Prolonged Islet Allograft Survival.

Transplantation·2026
Same journal

Desensitization With Tocilizumab and IVIg: A Prospective Controlled Cohort Study in a Predominantly Black American Population.

Transplantation·2026
Same journal

From Preservation to Repair: Clinical and Ethical Implications of Organ Reconditioning in the era of Machine Perfusion.

Transplantation·2026
See all related articles

Donor-derived soluble human leukocyte antigens (sHLA) are commonly detected after liver, kidney, and heart transplants. This finding suggests sHLA may play a role in transplant tolerance across various organs.

Area of Science:

  • Transplantation immunology
  • Immunogenetics

Background:

  • Transplanted organs, particularly livers, can secrete donor-type soluble human leukocyte antigens (sHLA) into recipient circulation.
  • This phenomenon defines recipients as serologic allogeneic chimeras.
  • The presence of soluble antigens is known to induce tolerance in animal models, suggesting biological importance in transplantation.

Purpose of the Study:

  • To investigate the prevalence of donor sHLA secretion after organ transplantation.
  • To determine if this phenomenon extends to organs beyond the liver, such as kidneys and hearts.

Main Methods:

  • Analysis of 445 serum samples from liver, kidney, and heart transplant recipients with functioning allografts (>1 year).
  • Quantification of specific sHLA (sHLA-A2, sHLA-A1/A3/A11) using enzyme-linked immunosorbent assay.

Related Experiment Videos

  • Selection of donor-recipient pairs with distinct allotypes to ensure detection of donor-derived sHLA.

    • Main Results:

    • All liver transplant recipients showed detectable donor sHLA.
    • Persistent donor sHLA was found in 72% of kidney and 50% of heart transplant recipients.
    • High and stable donor sHLA levels correlated with long-term allograft function.

    Conclusions:

    • Donor sHLA is consistently produced by transplanted livers, and frequently by kidneys and hearts.
    • The potential tolerogenic role of donor sHLA is applicable not only to liver transplants but also to kidney and heart transplants.