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Related Experiment Videos

Hair loss after routine immunizations

R P Wise1, K P Kiminyo, M E Salive

  • 1Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md 20852-1448, USA. wise@a1.cber.fda.gov

JAMA
|October 27, 1997
PubMed
Summary
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While rare, vaccinations may be associated with hair loss. This study reviewed reports and found a potential link, particularly with the hepatitis B vaccine, though more research is needed.

Area of Science:

  • Immunology
  • Dermatology
  • Pharmacovigilance

Background:

  • Alopecia (hair loss) is a known side effect of many medications.
  • Vaccines are not typically considered a cause of unexpected hair loss.

Observation:

  • This study analyzed case reports of hair loss following routine vaccinations.
  • Data was gathered from spontaneous reports to regulatory agencies and a case series with follow-up.

Findings:

  • Sixty reports of alopecia after immunization were reviewed, with 16 positive rechallenges.
  • Hepatitis B vaccines were most frequently implicated (46 cases).
  • Hair loss varied in onset, extent, and reversibility, with females predominating.

Implications:

Related Experiment Videos

  • A rare association between vaccinations and hair loss may exist.
  • Potential pathophysiologic mechanisms require further investigation.
  • Further research in defined populations is needed to confirm findings and rule out ascertainment bias.