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Related Experiment Videos

Vesicoureteral reflux

A B Belman1

  • 1Department of Pediatric Urology, Children's National Medical Center, Washington, DC, USA.

Pediatric Clinics of North America
|November 5, 1997
PubMed
Summary
This summary is machine-generated.

Minimally invasive endoscopic treatments for vesicoureteral reflux are evolving. Future safe and durable bulking agents could revolutionize reflux management, potentially eliminating the need for long-term medication and monitoring.

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Area of Science:

  • Urology
  • Minimally Invasive Surgery
  • Biomaterials Science

Background:

  • Current vesicoureteral reflux management relies on available treatment modalities.
  • Endoscopic outpatient treatment using bulking agents has been available for approximately a decade.

Purpose of the Study:

  • To review the current landscape of vesicoureteral reflux management.
  • To explore the potential impact of novel, safe, and durable minimally invasive treatments.

Main Methods:

  • Review of existing literature on vesicoureteral reflux treatments.
  • Discussion of endoscopic techniques and biomaterials used for ureteral orifice injection.
  • Evaluation of safety and durability concerns with current and investigational materials.

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Main Results:

  • Polytetrafluoroethylene (Teflon) particle injections raise safety concerns due to potential migration.
  • Cross-linked bovine collagen offers an alternative but lacks long-term durability.
  • Ongoing research focuses on safe and effective biomaterials like chondrocytes, bioglass microspheres, and detachable balloons.

Conclusions:

  • The development of a simple, successful, durable, and minimally invasive treatment for vesicoureteral reflux is anticipated to change current management paradigms.
  • Future endoscopic treatments with safe materials could enable immediate intervention for mild to moderate reflux, avoiding long-term prophylaxis and radiographic surveillance.