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Regulation of ion transport by protein-protein interaction domains
1Hospital for Sick Children, Division of Respiratory Research, Toronto, Ontario, Canada.
Current Opinion in Nephrology and Hypertension
|November 5, 1997
Abstract:
Protein-protein interaction via specific modular domains has been implicated in the regulation of many signalling pathways. Recently, such modules, in particular WW, Src homology-3 and PDZ domains, have been shown to regulate localization, clustering and function of several ion channels and transporters, including the epithelial Na+ channel, K+ channel and ionotropic neurotransmitter receptors.