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Updated: Aug 14, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Hyperhomocysteinemia: detection, risk assessment, and treatment
V W Dennis1, S Nurko, K Robinson
1Department of Nephrology and Hypertension, Cleveland Clinic Foundation, OH 44195, USA. dennisv@cesmtp.ccf.org
Abstract:
Homocysteine is formed by the demethylation of methionine in the course of its normal metabolism. Hyperhomocysteinemia is an independent risk factor for vascular disease. It develops most commonly from folate deficiency, genetic abnormalities, and chronic renal failure. Current models favor direct angiotoxicity involving endothelial and vascular smooth muscle cells, and impaired thrombolysis. Folic acid reduces hyperhomocysteinemia and thus provides an opportunity for risk-factor modification.
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