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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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HIV-associated lymphomas

D J Straus1

  • 1Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Current Opinion in Oncology
|November 5, 1997
PubMed

Intermediate and high-grade non-Hodgkin's lymphomas (NHL) with a B-cell phenotype are AIDS-defining illnesses. The incidence of systemic NHL increased greatly and primary central nervous system NHL increased even more in the HIV-infected population. Further increases in frequency are anticipated as HIV-infected individuals survive longer in an immunosuppressed state with improved antiretroviral treatment and treatment of opportunistic infections. Unusual types of NHL and manifestations of Hodgkin's disease are seen in HIV-infected individuals also. The pathologic and clinical features of the HIV-associated lymphomas and treatment approaches and results are the subjects of this review. Other articles in this issue discuss epidemiology and pathogenesis.

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