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Experimental models of gene-environment interaction for cancer chemoprevention studies

S D Hursting1

  • 1Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

Current Opinion in Oncology
|November 5, 1997
PubMed

Insights

Genetically altered mouse models, including Min, APC-knockout, and p53-knockout mice, are crucial for testing cancer chemoprevention. Cyclooxygenase-2 inhibitors show promise for colon cancer prevention.

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Background:

  • Genetically engineered mouse models (GEMMs) are vital for cancer research.
  • Specific mouse strains with altered cancer-related genes aid in testing chemoprevention strategies.
  • This review highlights key GEMMs used in chemoprevention studies.

Purpose of the Study:

  • To review the utility of specific genetically altered mouse models in cancer chemoprevention research.
  • To discuss the role of cyclooxygenase-2 in colon carcinogenesis.
  • To explore the potential of chemopreventive agents in p53-deficient mice.

Main Methods:

  • Focus on Min mice (adenomatous polyposis coli gene mutation).
  • Analysis of APC-knockout mice.
  • Review of p53-knockout mouse studies for chemoprevention.

Main Results:

  • Min and APC-knockout mice provide strong evidence for cyclooxygenase-2's role in colon cancer.
  • Nonsteroidal anti-inflammatory drugs targeting cyclooxygenase-2 show potential for colon cancer chemoprevention.
  • Chemoprevention may offset cancer susceptibility in p53-deficient mice.

Conclusions:

  • Genetically altered mouse models are indispensable tools for advancing cancer chemoprevention.
  • Targeting cyclooxygenase-2 is a promising strategy for colon cancer prevention.
  • Further research into chemoprevention for genetically susceptible mouse models is warranted.

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