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Cortical development and thalamic pathology in schizophrenia

E G Jones1

  • 1Dept. of Anatomy and Neurobiology, University of California-Irvine 92717, USA.

Schizophrenia Bulletin
|January 1, 1997
PubMed
Summary

Schizophrenia may involve altered brain development, particularly in neural connections. This could lead to thought process disintegration due to impaired thalamic and cortical neuron communication.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Biology

Background:

  • Schizophrenia is a complex mental disorder with suspected neurodevelopmental origins.
  • While gross brain structural abnormalities are not consistently found, subtle alterations in neural development are hypothesized.

Purpose of the Study:

  • To review morphological data on brain development in schizophrenia.
  • To explore potential pathological involvement in neural development processes.

Main Methods:

  • Review of existing morphological data and developmental neuroscience literature.
  • Analysis of how developmental processes might be altered in schizophrenia.

Main Results:

  • Developmental processes like connection establishment, refinement, and maintenance are potential sites of pathology in schizophrenia.
  • Alterations in neural connections may lead to changes in gene expression and neurotransmission.
  • Thalamic cell loss, potentially primary or secondary, is implicated.

Conclusions:

  • Impaired corticothalamic connectivity due to cell loss may disrupt functional brain states.
  • Failure in collective neural oscillations between cortical and thalamic neurons could underlie thought disintegration in schizophrenia.

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