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Reduction of malachite green to leucomalachite green by intestinal bacteria
A L Henderson1, T C Schmitt, T M Heinze
1National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA.
Applied and Environmental Microbiology
|November 5, 1997
Abstract:
Intestinal microfloras from human, rat, mouse, and monkey fecal samples and 14 pure cultures of anaerobic bacteria representative of those found in the human gastrointestinal tract metabolized the triphenylmethane dye malachite green to leucomalachite green. The reduction of malachite green to the leuco derivative suggests that intestinal microflora could play an important role in the metabolic activation of the triphenylmethane dye to a potential carcinogen.