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Effect of demethylation on the chitinase inhibitory activity of allosamidin
K D Spindler1, M Spindler-Barth, S Sakuda
1Department of General Zoology, University of Ulm. spindler@biofs1.biologie.uni-ulm.de
Archives of Insect Biochemistry and Physiology
|January 1, 1997
Abstract:
Removal of a methyl group of the allosamizoline moiety of allosamidin decreases the inhibitory effect on family 18 chitinases from three different species (a bacterium, Serratia marcescens, a crustacean, Artemia salina, and an insect cell line, Chironomus tentans). Loss of a second methyl group weakens enzyme inhibition further. This is in agreement with the highly conserved catalytic centre of these enzymes.