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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Published on: May 14, 2013

Health after coronary stenting or balloon angioplasty: results from the Stent Restenosis Study

H M Krumholz1, D J Cohen, C Williams

  • 1Department of Medicine, Yale School of Medicine, New Haven, CT 06520-8025, USA.

American Heart Journal
|November 5, 1997
PubMed

Insights

Coronary stenting and balloon angioplasty showed similar long-term health-related quality of life (HRQOL) outcomes. Patients receiving stenting reported less bodily pain, but overall HRQOL and symptom status were comparable between groups.

Area of Science:

  • Cardiovascular Medicine
  • Health Outcomes Research
  • Interventional Cardiology

Background:

  • Percutaneous coronary interventions, including balloon angioplasty and coronary stenting, are common treatments for coronary artery disease.
  • Assessing long-term health-related quality of life (HRQOL) is crucial for evaluating treatment efficacy beyond clinical endpoints.
  • The Stent Restenosis Study provided a randomized comparison of Palmaz-Schatz coronary stenting versus conventional balloon angioplasty.

Purpose of the Study:

  • To compare health-related quality of life (HRQOL) in patients who underwent coronary stenting versus balloon angioplasty.
  • To evaluate differences in generic and disease-specific HRQOL measures at 6 to 18 months post-procedure.
  • To determine if stenting offers superior long-term quality of life compared to angioplasty.

Main Methods:

  • A randomized trial comparing Palmaz-Schatz coronary stent implantation with conventional balloon angioplasty.
  • 160 out of 199 patients (80%) returned surveys 6 to 18 months after randomization.
  • Surveys included the Medical Outcomes Study 36-Item Short-Form Health Survey, Canadian Cardiovascular Society Classification, and Duke Activity Status Index.

Main Results:

  • Patients undergoing stenting experienced less angiographic restenosis and a trend towards fewer ischemic events.
  • The stenting group reported significantly less bodily pain (p = 0.02) compared to the angioplasty group.
  • No significant differences were observed in other generic or disease-specific HRQOL measures; overall health and symptom-free rates were similar.

Conclusions:

  • Long-term HRQOL outcomes between Palmaz-Schatz coronary stenting and conventional balloon angioplasty are largely comparable.
  • While stenting may reduce bodily pain, it does not confer a marked advantage in overall or disease-specific quality of life.
  • Both interventions resulted in similar high rates of perceived overall health and cardiovascular symptom freedom.

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