Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Haemostatic changes during surgery for primary brain tumours

K Y Goh¹, W C Tsoi, C S Feng

¹Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories.

Journal of Neurology, Neurosurgery, and Psychiatry

|November 5, 1997

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular stratification of gliomas using next-generation sequencing: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2025

Same author

Impact of iron deficiency on attention among school-aged adolescents in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2025

Same author

Multicentre study of hospitalised patients with sports- and recreational cycling-related traumatic brain injury in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2021

Same author

A Full-Color Electroluminescent Device and Patterned Photoalignment Using Light-Emitting Liquid Crystals.

Advanced materials (Deerfield Beach, Fla.)·2021

Same author

Antioxidative effect of Gastrodiae Rhizoma-containing herbal formula in PC12 cell model: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2020

Same author

<i>Streptococcus bovis</i> bacteraemia should be investigated for early detection of colorectal pathology.

Hong Kong medical journal = Xianggang yi xue za zhi·2019

Same journal

Global epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Journal of neurology, neurosurgery, and psychiatry·2026

Same journal

Diagnostic accuracy of a two-cut-off approach using the FAQ/MMSE ratio and FAQ for clinical preselection of patients for anti-amyloid therapy.

Journal of neurology, neurosurgery, and psychiatry·2026

Same journal

Cancer risk and mortality in patients with multiple sclerosis in Finland: a retrospective population-based cohort study.

Journal of neurology, neurosurgery, and psychiatry·2026

Same journal

Visuospatial working memory in Huntington's disease: behavioural and structural brain correlates.

Journal of neurology, neurosurgery, and psychiatry·2026

Same journal

Characteristics and outcomes in electric scooter-related traumatic brain injuries in Helsinki.

Journal of neurology, neurosurgery, and psychiatry·2026

Same journal

Chronological ageing and ovarian reserve in MS: insights from anti-Müllerian hormone and disability progression.

Journal of neurology, neurosurgery, and psychiatry·2026

See all related articles

Thromboelastography (TEG) revealed coagulation abnormalities in brain tumor patients during surgery. Some patients showed hypercoagulability, while others had a predisposition to hypocoagulability before surgery.

Area of Science:

Neurosurgery
Hematology
Anesthesiology

Background:

Primary brain tumors can cause coagulation disorders, complicating surgical management.
Thromboelastography (TEG) offers a comprehensive assessment of blood clot formation and stability.

Purpose of the Study:

To evaluate the coagulation profile of patients with primary brain tumors undergoing surgery.
To assess the utility of TEG in conjunction with standard laboratory tests for managing coagulation disorders.

Main Methods:

A prospective observational study of 50 adult patients with large primary brain tumors (>4 cm).
Preoperative, intraoperative, and postoperative measurements included hemoglobin, platelets, PT, PTT, FDPs, D-dimer, and TEG analysis.
Patients had no prior history of coagulation disorders.

Related Experiment Videos

Main Results:

Twenty-two percent of patients (11/50) exhibited abnormal intraoperative TEGs.
Twelve percent (6/50) developed postoperative hematomas requiring surgical evacuation.
TEG identified hyperfibrinolysis in 4% and disseminated intravascular coagulation in 8% of patients.
Preoperative TEG showed a predisposition to hypocoagulability in some patients, indicated by prolonged K time and reduced clot strength (MA), which correlated with hematoma development.

Conclusions:

Brain tumor surgery is associated with a general tendency towards hypercoagulability, but some patients may have an underlying hypocoagulable state detectable by TEG.
Intraoperative TEG abnormalities warrant prompt management with clotting factors, platelets, or antifibrinolytics, irrespective of standard laboratory results.