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Related Experiment Videos

Premenstrual syndromes

M I Korzekwa1, M Steiner

  • 1Department of Psychiatry, St. Joseph's Hospital, Hamilton, Ontario, Canada.

Clinical Obstetrics and Gynecology
|November 5, 1997
PubMed
Summary
This summary is machine-generated.

Premenstrual syndrome (PMS) diagnosis has advanced, with new criteria for Premenstrual Dysphoric Disorder (PMDD) identifying severe cases. Effective treatments are available for PMDD, targeting the serotonin system and ovulation triggers.

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Area of Science:

  • Gynecology
  • Psychiatry
  • Neuroendocrinology

Background:

  • Diagnostic criteria for Premenstrual Syndrome (PMS) were established in 1983, advancing research.
  • Prospective diagnosis and exclusion of other disorders marked significant methodological progress.
  • The DSM-IV criteria for Premenstrual Dysphoric Disorder (PMDD) aid in classifying severe premenstrual psychological symptoms.

Purpose of the Study:

  • To review the progress in Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) diagnosis and treatment.
  • To highlight the current understanding of PMDD etiology and therapeutic options.

Main Methods:

  • Review of diagnostic criteria evolution for PMS and PMDD.
  • Discussion of the proposed pathophysiology involving the serotonin system and ovulation.

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  • Overview of treatment strategies based on diagnostic classification.

    • Main Results:

    • The consensus suggests PMDD results from complex events, partly mediated by the serotonin system and triggered by ovulation.
    • Conservative treatment is recommended for PMS without PMDD or concurrent disorders.
    • Successful treatment for PMDD includes low-dose clomipramine, SSRIs, or GnRH-agonists with hormone replacement.

    Conclusions:

    • Advances in diagnostic criteria have improved the identification and classification of PMS and PMDD.
    • Understanding the role of the serotonin system and ovulation is key to PMDD pathophysiology.
    • Tailored treatment approaches, from conservative management to pharmacotherapy, are effective for PMS and PMDD.