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Basic fibroblast growth factor and platelet-derived growth factor prevent the death of spinal motor neurons after
Y Iwasaki1, T Shiojima, N Tagaya
1Fourth Department of Internal Medicine, Toho University, Ohashi Hospital, Tokyo, Japan.
Neurological Research
|November 5, 1997
Abstract:
In vivo, motor neurons are destined to die after axotomy. Several neuronal growth factors, such as ciliary neurotrophic factor, brain-derived neurotrophic factor, and leukemia inhibitory factor rescue neuronal death of axotomized motor neurons. Here, we report that systemically administered basic fibroblast growth factor and platelet-derived growth factor prevented spinal motor neuron death in neonatal rats following sciatic nerve resection. These data indicate that basic fibroblast growth factor and platelet derived growth factor play a role for motor neuron survival in vivo.