Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticosteroids decrease exhaled nitric oxide in children with acute asthma

E Baraldi1, N M Azzolin, S Zanconato

  • 1Department of Pediatrics, School of Medicine, Padova, Italy.

The Journal of Pediatrics
|November 5, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-Effectiveness Analysis of Nirsevimab for the Prevention of Respiratory Syncytial Virus among Italian Infants.

Clinical drug investigation·2025
Same author

Comparison of "IN-REC-SUR-E" and LISA in preterm neonates with respiratory distress syndrome: a randomized controlled trial (IN-REC-LISA trial).

Trials·2024
Same author

Bioactivity of volatile organic compounds by Aureobasidium species against gray mold of tomato and table grape.

World journal of microbiology & biotechnology·2020
Same author

First Report of Asiatic Brown Rot Caused by Monilinia polystroma on Peach in Italy.

Plant disease·2019
Same author

Effect of Aureobasidium pullulans strains against Botrytis cinerea on kiwifruit during storage and on fruit nutritional composition.

Food microbiology·2018
Same author

Priorities for future research into asthma diagnostic tools: A PAN-EU consensus exercise from the European asthma research innovation partnership (EARIP).

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same journal

Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Controlled Trial.

The Journal of pediatrics·2026
Same journal

Does Mild Head Injury in Childhood Affect Later School Performance? A Sibling Comparison Cohort Study.

The Journal of pediatrics·2026
Same journal

Risk Factors for Mortality and Age at Discharge in Preterm Infants with Congenital Heart Disease.

The Journal of pediatrics·2026
Same journal

Safety of 20-Valent Pneumococcal Conjugate Vaccine (PCV20) in Children in the Vaccine Adverse Event Reporting System.

The Journal of pediatrics·2026
Same journal

Association between Salivary Substance P and Aspiration on Videofluoroscopic Swallow Study in Infants and Toddlers.

The Journal of pediatrics·2026
Same journal

Postoperative Intensive Care Unit Stay After Congenital Lung Malformation Resection: Not Always a Necessary Stop.

The Journal of pediatrics·2026
See all related articles

Children with asthma exacerbation show high exhaled nitric oxide (NO) levels. Oral steroid therapy significantly reduced NO, suggesting it

Area of Science:

  • Respiratory Medicine
  • Pediatric Pulmonology
  • Biomarkers of Inflammation

Background:

  • Nitric oxide (NO) plays a dual role in the respiratory system, with elevated levels observed in asthmatic adults.
  • Previous studies indicate higher exhaled NO in adult asthmatics compared to healthy individuals.

Purpose of the Study:

  • To investigate exhaled NO production in children experiencing asthma exacerbations.
  • To assess the impact of oral steroid therapy on exhaled NO levels in pediatric asthma.

Main Methods:

  • Exhaled NO was measured in 16 children with acute asthma and 16 healthy children using chemiluminescence analysis.
  • Measurements were taken before and after a 5-day course of oral prednisone in the asthma group.
  • Bronchodilator response was assessed in stable asthmatic children to evaluate its effect on NO levels.

Related Experiment Videos

Main Results:

  • Children with acute asthma exhibited significantly higher exhaled NO levels (31.3 ppb) than healthy controls (5.4 ppb).
  • Five days of oral prednisone therapy led to a 46% decrease in exhaled NO and improved lung function.
  • Post-treatment NO levels in asthmatic children remained elevated compared to controls, and bronchodilator response did not affect NO measurements.

Conclusions:

  • Children with asthma exacerbations present with elevated exhaled NO, which is responsive to oral steroid treatment.
  • Exhaled NO measurement offers a potential noninvasive tool for monitoring airway inflammation in pediatric asthma.