Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Errors involved in instantaneous intravascular input assumptions

S Niazi

    Journal of Pharmaceutical Sciences
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Viable viruses in airborne particles detected during cough by participants with acute respiratory viral infections.

    The Journal of hospital infection·2025
    Same author

    Simulation of pollen-humidity interactions and origin of airborne sub-pollen particles.

    The Science of the total environment·2025
    Same author

    The emergence of enterovirus D68 in England in autumn 2014 and the necessity for reinforcing enterovirus respiratory screening.

    Epidemiology and infection·2017
    Same author

    The effectiveness of passive ultrasonic irrigation on intraradicular Enterococcus faecalis biofilms in extracted single-rooted human teeth.

    International endodontic journal·2010
    Same author

    Oral health and related quality of life status in patients from UK and Turkey: a comparative study in Behcet's disease.

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2009
    Same author

    Detection of DNA by scraping the formalin-fixed paraffin-embedded tissue.

    Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2008

    This study compares zero-order input to instantaneous intravascular input assumptions in pharmacokinetic models. Results suggest treating all intravascular administrations as zero-order inputs for improved accuracy.

    Area of Science:

    • Pharmacokinetics
    • Mathematical Modeling

    Background:

    • The assumption of instantaneous intravascular input is widely used in pharmacokinetic modeling.
    • This assumption may introduce errors in model predictions.
    • Understanding input kinetics is crucial for accurate drug disposition analysis.

    Purpose of the Study:

    • To comparatively evaluate zero-order input versus instantaneous intravascular input assumptions.
    • To quantify the error associated with the instantaneous input assumption in pharmacokinetic models.
    • To propose an alternative input model for intravascular drug administration.

    Main Methods:

    • Development of mathematical equations for two- and three-compartment open model systems.
    • Comparative analysis of zero-order input and instantaneous intravascular input models.

    Related Experiment Videos

  • Creation of a nomogram to determine the magnitude of error.

    • Main Results:

    • The instantaneous intravascular input assumption can lead to significant errors.
    • The derived nomogram quantifies the error magnitude based on model parameters.
    • Zero-order input provides a more accurate representation for certain administration scenarios.

    Conclusions:

    • The instantaneous intravascular input assumption may not always be appropriate.
    • Zero-order input modeling is recommended for intravascular administrations.
    • This approach can enhance the accuracy of pharmacokinetic predictions.