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Cerebrovascular pathology in Alzheimer's disease: cause, effect or epiphenomenon?
1Department of Clinical Neurological Sciences, London Health Sciences Center, University of Western Ontario, Canada.
Abstract:
Cerebrovascular pathology abounds in Alzheimer's disease. Changes in the endothelium, disruption of the blood-brain barrier and amyloid deposition in the cerebral blood vessels are almost universal in advanced cases. Do these changes represent the cause, the effect, or the consequences of a common pathogenesis of Alzheimer's disease? This volume addresses some of these issues by presenting new knowledge gained from a diversity of fields. Recognition of the mechanisms involved will open new possibilities for therapeutic trials.
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