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Related Experiment Videos

The malarial fever response--pathogenesis, polymorphism and prospects for intervention

D Kwiatkowski1, C A Bate, I G Scragg

  • 1Department of Paediatrics, John Radcliffe Hospital, Oxford, U.K. dominic@immsvr.jr2.ox.ac.uk

Annals of Tropical Medicine and Parasitology
|July 1, 1997
PubMed
Summary

Malaria fever, caused by tumor necrosis factor (TNF), affects millions yearly. Research explores parasite components and host factors influencing TNF production to combat severe malaria.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Malariology

Background:

  • Malaria causes over 200 million debilitating fevers and 2 million deaths annually.
  • Fever results from host immune response to malaria parasite products, involving tumor necrosis factor (TNF) and pyrogenic cytokines.
  • Excessive TNF production is implicated in severe malaria pathogenesis, despite its anti-parasitic properties.

Purpose of the Study:

  • To review molecular characterization of parasite components triggering host TNF response.
  • To define host and parasite factors influencing TNF production levels.
  • To understand mechanisms potentially relevant for malaria therapeutics.

Main Methods:

  • Review of recent research on molecular triggers of TNF response.
  • Analysis of host and parasite factors affecting TNF levels.

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  • Examination of host polymorphisms and acquired antibodies impacting TNF induction.

    • Main Results:

    • Identification of parasite components stimulating host TNF response is ongoing.
    • Host genetic variations (polymorphisms) and acquired antibodies correlate with malaria severity by affecting TNF levels.
    • Understanding of TNF regulation in malaria pathogenesis remains limited.

    Conclusions:

    • Further research is needed to fully characterize parasite-host interactions in TNF production.
    • Host factors like genetic polymorphisms and antibodies are crucial in modulating malaria severity.
    • Targeting TNF pathways holds therapeutic potential but requires deeper molecular and epidemiological insights.