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Allergic contact dermatitis from tromantadine

I Jáuregui1, I Urrutia, P M Gamboa

  • 1Allergology Section, Hospital de Basurto, Bilbao, Spain.

Journal of Investigational Allergology & Clinical Immunology
|July 1, 1997
PubMed
Summary

Tromantadine, a topical antiviral, can cause allergic contact dermatitis, even when used for lip herpes. This case highlights the risk of sensitization to tromantadine, an agent still in use in Europe.

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Tromantadine is a topical antiviral medication derived from amantadine.
  • It is frequently prescribed as a second-line treatment for herpes labialis (lip herpes) in several European countries.
  • Previous studies indicate a 5% incidence of contact allergy to tromantadine.

Observation:

  • A 28-year-old woman experienced a severe exacerbation of her lip herpes following treatment with tromantadine ointment.
  • Diagnostic patch testing revealed a strong positive reaction to tromantadine.

Findings:

  • The patient developed allergic contact dermatitis attributed to tromantadine.
  • This case underscores the potential for tromantadine sensitization.

Implications:

  • Healthcare providers should be aware of the risk of tromantadine allergy.
  • Increased vigilance and potential re-evaluation of tromantadine's use may be warranted given its continued prescription.
  • Further research into alternative topical treatments for herpes labialis could be beneficial.

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