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Related Experiment Videos

Polyhedral non-ionic surfactant vesicles

I F Uchegbu1, A Schätzlein, G Vanlerberghe

  • 1Centre for Drug Delivery Research, School of Pharmacy, University of London, UK.

The Journal of Pharmacy and Pharmacology
|June 1, 1997
PubMed
Summary

Novel non-ionic surfactant vesicles (niosomes) demonstrate thermo-responsive drug release for sustained delivery. These polyhedral vesicles maintain structure while increasing permeability with temperature, ideal for ophthalmic and injectable applications.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biotechnology

Background:

  • Non-ionic surfactant vesicles, or niosomes, are investigated for drug delivery.
  • Formulations utilizing hexadecyl diglycerol ether (C16G2), cholesteryl poly-24-oxyethylene ether (Solulan C24), and cholesterol are explored.
  • Niosomes are being developed as slow-release systems for ophthalmic, subcutaneous, and intramuscular administration.

Purpose of the Study:

  • To investigate the potential of specific non-ionic surfactant vesicles as slow-release drug delivery systems.
  • To characterize the phase behavior and morphology of a three-component niosome system.
  • To evaluate the thermo-responsive release characteristics of entrapped model drugs.

Main Methods:

  • Construction of a phase diagram for the C16G2, Solulan C24, and cholesterol system.

Related Experiment Videos

  • Confocal laser-scanning microscopy to analyze vesicle morphology.
  • Study of the release kinetics of carboxyfluorescein and nicotinamide adenine dinucleotide at varying temperatures.

    • Main Results:

    • Polyhedral vesicles were formed and identified to be in the gel (L beta) phase.
    • Confocal microscopy confirmed the complex, polyhedral structure of the vesicles.
    • Increased temperature (37°C) enhanced the release of entrapped substances, despite the vesicles retaining their shape.

    Conclusions:

    • The investigated niosomes exhibit thermo-responsive drug release properties.
    • Reversible changes in bilayer permeability, influenced by temperature-induced alterations in the polyethoxylated cholesterol ether's membrane packing, drive the thermo-responsive release.
    • These niosomes show promise for controlled and sustained drug delivery applications.