Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current perspectives in gliomas

C S Brock1, M Bower

  • 1Medical Oncology Unit, Charing Cross Hospital, London, UK.

Medical Oncology (Northwood, London, England)
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human immunodeficiency virus-associated lymphomas: EHA-ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Taxonomic reclassification of Kaposi Sarcoma identifies disease entities with distinct immunopathogenesis.

Journal of translational medicine·2023
Same author

Local excision and treatment of early node-negative anal squamous cell carcinomas in a highly HIV prevalent population.

Techniques in coloproctology·2021
Same author

Improving outcomes for the treatment of Anal Squamous Cell Carcinoma and Anal Intraepithelial Neoplasia.

Techniques in coloproctology·2019
Same author

The prognostic and predictive role of hyponatremia in patients with advanced non-small cell lung cancer (NSCLC) with bone metastases.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2018
Same author

Functional immune characterization of HIV-associated non-small-cell lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology·2018
Same journal

DC-intrinsic SHP1 restrains central memory CD8⁺ T cell formation via the TCF-1/Wnt/β-Catenin axis.

Medical oncology (Northwood, London, England)·2026
Same journal

Site-specific trastuzumab Fab-DM1 via butelase-1 with ABD fusion for potent HER2-positive tumor control.

Medical oncology (Northwood, London, England)·2026
Same journal

Unraveling the link between genomic instability and tumor immune evasion in oral squamous cell carcinoma: Role of CBMN assay and emerging perspectives.

Medical oncology (Northwood, London, England)·2026
Same journal

Novel patient-derived tongue squamous cell carcinoma cell lines from non-smokers: 3D and in vivo models for drug response studies.

Medical oncology (Northwood, London, England)·2026
Same journal

Decoy oligonucleotide technology in cancer therapy: molecular mechanisms, challenges, and translational potential.

Medical oncology (Northwood, London, England)·2026
Same journal

The translational roles of circular RNAs in cancers and their underlying molecular mechanisms.

Medical oncology (Northwood, London, England)·2026
See all related articles

Primary central nervous system tumors, including gliomas, have increasing incidence but poor prognosis. Advances in imaging, neurosurgery, and radiotherapy improve management, but targeted therapies offer future promise.

Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Radiation Oncology

Background:

  • The incidence of primary central nervous system tumors, particularly gliomas, is rising, yet patient prognosis remains poor with a median survival of only five years.
  • Despite advancements in diagnostic imaging techniques like computed tomography, magnetic resonance imaging, positron emission tomography, and proton magnetic resonance spectroscopy (1H-MRS), understanding of tumor biology and extent is still evolving.
  • Current treatment modalities have seen improvements, but effective long-term survival benefits are limited.

Purpose of the Study:

  • To provide an overview of current perspectives in glioma management.
  • To highlight recent advancements in diagnostic and therapeutic strategies for gliomas.
  • To discuss the evolving role of chemotherapy and the promise of targeted therapies.

Related Experiment Videos

Main Methods:

  • Review of current literature on glioma diagnosis and treatment.
  • Analysis of advancements in neuroimaging, neurosurgery, and radiotherapy.
  • Evaluation of the efficacy of adjuvant chemotherapy and emerging targeted therapies.

Main Results:

  • Imaging technologies enhance knowledge of tumor biology and extent.
  • Neurosurgical and radiotherapy techniques have improved initial tumor management, reducing mortality and morbidity.
  • Adjuvant chemotherapy's role is controversial, with no documented survival prolongation for advanced or recurrent disease, though quality of life may improve.

Conclusions:

  • While current treatments offer incremental benefits, the prognosis for gliomas remains challenging.
  • Targeted therapies, informed by increasing knowledge of glioma physiology and molecular biology, represent a promising future direction.
  • Continued research into genetic-level targeting is crucial for improving glioma patient outcomes.