Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules

C G Gahmberg1

  • 1Department of Biosciences, University of Helsinki, Finland. Carl.Gahmberg@Helsinki.Fi

Current Opinion in Cell Biology
|October 23, 1997
PubMed
Summary

Leukocyte integrins and intercellular adhesion molecules are key to cell adhesion. Recent research has advanced understanding of their structures, binding sites, activation, and roles in disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A tripeptide mimetic of von Willebrand factor residues 981-983 enhances platelet adhesion to fibrinogen by signaling through integrin alpha(IIb)beta3.

Journal of thrombosis and haemostasis : JTH·2005
Same author

Differential expression of cytokines (IL-2, IFN-gamma, IL-10) and adhesion molecules (VCAM-1, LFA-1, CD44) between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis.

Scandinavian journal of immunology·2002
Same author

Release of soluble ICAM-5, a neuronal adhesion molecule, in acute encephalitis.

Neurology·2002
Same author

Intercellular adhesion molecule-1 in extravasation of normal mononuclear and leukaemia cells.

British journal of haematology·2001
Same author

Inhibition of beta(2) integrin-mediated leukocyte cell adhesion by leucine-leucine-glycine motif-containing peptides.

The Journal of cell biology·2001
Same author

An essential role for calmodulin in regulating human T cell aggregation.

FEBS letters·2001

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Leukocyte integrins and intercellular adhesion molecules are crucial for leukocyte adhesion to cells and extracellular matrices.
  • Recent discoveries have identified novel intercellular adhesion molecules.
  • Significant information on the structures and binding sites of these adhesion molecules has been gathered.

Purpose of the Study:

  • To review recent advancements in the understanding of leukocyte integrins and intercellular adhesion molecules.
  • To highlight progress in studying integrin activation.
  • To explore the role of leukocyte adhesion molecules in various diseases.

Main Methods:

  • Literature review of recent studies on leukocyte integrins and intercellular adhesion molecules.

Related Experiment Videos

  • Analysis of structural and binding site data.
  • Examination of research on integrin activation mechanisms.
  • Review of studies investigating the involvement of adhesion molecules in disease pathogenesis.

    • Main Results:

    • New intercellular adhesion molecules have been identified.
    • Detailed structural and binding site information for leukocyte integrins and intercellular adhesion molecules is now available.
    • Substantial progress has been made in understanding integrin activation processes.
    • The critical role of leukocyte adhesion molecules in disease pathogenesis is increasingly recognized.

    Conclusions:

    • Leukocyte integrins and intercellular adhesion molecules are fundamental to immune cell function and disease.
    • Continued research into these molecules promises further insights into cell adhesion and therapeutic strategies.
    • Understanding integrin activation and the function of adhesion molecules is vital for addressing inflammatory and immune-related disorders.