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The dermal-epidermal junction

R E Burgeson¹, A M Christiano

¹Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA.

Current Opinion in Cell Biology

|October 23, 1997

Summary

Understanding the dermal-epidermal junction

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Area of Science:

Dermatology and molecular biology of the skin's dermal-epidermal junction.

Background:

Inherited blistering skin disorders reveal gene mutations affecting the dermal-epidermal junction.
Knockout mouse models further elucidate the function of these genes and proteins.

Purpose of the Study:

To integrate findings from genetic studies and cell biology analyses.
To develop a comprehensive model of the dermal-epidermal junction's structure and function.

Main Methods:

Studying inherited blistering skin disorders to identify gene mutations.
Utilizing targeted gene ablation in knockout mouse models.
Performing cell biology analyses of the hemidesmosome/anchoring filament complex.

Main Results:

Identified functionally important interactions between structural proteins.
Demonstrated the role of specific proteins in cell adhesion, migration, and signal transduction.
Revealed differential cell type-specific expression of cutaneous adhesion zone proteins.

Conclusions:

A new model of the dermal-epidermal junction integrates hemidesmosomal and interhemidesmosomal attachments.
This model highlights the importance of specific proteins in mediating adhesion and cellular communication.
Advances in understanding the dermal-epidermal junction are driven by genetic and cell biology approaches.

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