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Related Experiment Videos

Age-related decrease in the N-methyl-D-aspartateR-mediated excitatory postsynaptic potential in hippocampal region

C A Barnes1, G Rao, J Shen

  • 1Department of Psychology, University of Arizona, Tucson 85724, USA.

Neurobiology of Aging
|July 1, 1997
PubMed
Summary
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Aging impairs glutamatergic fast synaptic transmission in the hippocampus, with specific changes in CA1 and fascia dentata regions. This suggests differential age-related alterations in neurotransmitter receptor subtypes.

Area of Science:

  • Neuroscience
  • Aging Research
  • Synaptic Plasticity

Background:

  • Fast synaptic transmission mediated by glutamate is crucial for memory.
  • Age-related cognitive decline is associated with alterations in hippocampal synaptic function.
  • Previous studies indicate region-specific changes in aging brains.

Purpose of the Study:

  • To investigate age-related changes in glutamatergic synaptic transmission in the CA1 region of the hippocampus.
  • To compare these changes with those in the fascia dentata.
  • To test the hypothesis of reduced Schaffer collateral synapses in aging rats.

Main Methods:

  • Electrophysiological recordings of presynaptic fiber potentials and synaptic responses (non-NMDAR and NMDAR-mediated) in CA1 and fascia dentata.

Related Experiment Videos

  • Behavioral characterization of male F-344 rats of three different age groups.
  • Stimulation at various levels to assess synaptic responses relative to presynaptic input.

    • Main Results:

    • In the CA1 region, old rats exhibited equivalent reductions in non-NMDAR and NMDAR-excitatory postsynaptic potential amplitudes.
    • No changes were observed in the magnitude of the presynaptic response in CA1 across age groups.
    • In contrast, the fascia dentata showed an increased non-NMDAR-excitatory postsynaptic potential but a reduced NMDAR-excitatory postsynaptic potential.

    Conclusions:

    • Age-related synaptic alterations in the hippocampus are region-specific.
    • The findings in CA1 support a reduction in the number of Schaffer collateral synapses per axon.
    • Functional changes in neurotransmitter receptor subtypes differ between closely related hippocampal subregions during aging.