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New and potent inhibitors of nitric oxide synthase reduce motor activity in mice
E Dzoljic1, R De Vries, M R Dzoljic
1Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands.
Behavioural Brain Research
|October 23, 1997
Abstract:
Potent inhibitors of nitric oxide synthase (NOS), 3-bromo-7-nitro indazole, 1-(2-trifluoromethylphenyl)imidazole, S-methyl-L-thiocitrulline and 7-nitro indazole, reduced locomotion in mice. These results suggest that activity of NOS and corresponding NO release are of importance for normal locomotion.