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Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity
1Department of Bioengineering, Tokyo Institute of Technology, Yokohama, Japan.
Biological & Pharmaceutical Bulletin
|October 23, 1997
Abstract:
Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.