Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pulmonary capillary permeability - a transfusion lesion

I R Berman, H Iliescu, J H Ranson

    The Journal of Trauma
    |June 1, 1976
    PubMed
    Summary

    Massive blood transfusions can harm the lungs by increasing pulmonary capillary permeability, especially due to platelets in stored blood. Removing platelets and buffy coat mitigates this transfusion-related lung injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Docetaxel and nab-paclitaxel are safe alternative options for patients with gynecologic malignancies following hypersensitivity reaction to paclitaxel.

    European journal of gynaecological oncology·2018
    Same author

    Use of hematologic biomarkers during chemotherapy predicts survival in ovarian cancer patients.

    European journal of gynaecological oncology·2018
    Same author

    Revealing complete complex KIR haplotypes phased by long-read sequencing technology.

    Genes and immunity·2017
    Same author

    Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis.

    Leukemia·2017
    Same author

    The CD47 "don't eat me signal" is highly expressed in human ovarian cancer.

    Gynecologic oncology·2016
    Same author

    Reduced Sensitivity to Charge Noise in Semiconductor Spin Qubits via Symmetric Operation.

    Physical review letters·2016

    Area of Science:

    • Cardiovascular and Respiratory System Physiology
    • Transfusion Medicine
    • Pulmonary Research

    Background:

    • Massive bank blood transfusion is linked to post-injury pulmonary insufficiency.
    • Stored blood contains debris, but its direct pulmonary effect is unclear.
    • Pulmonary insufficiency often correlates with increased lung water.

    Purpose of the Study:

    • To investigate the pulmonary effects of blood transfusion in rats.
    • To measure pulmonary capillary permeability changes post-transfusion.
    • To identify blood components responsible for transfusion-induced lung injury.

    Main Methods:

    • Rats were transfused with blood and blood components.
    • Pulmonary capillary permeability was measured.

    Related Experiment Videos

  • Experiments compared transfusions with and without platelets and buffy coat.
  • Blood storage duration and container type effects were assessed.

    • Main Results:

    • The rat lung is a target organ for blood transfusion effects.
    • Transfusion causes acute increases in pulmonary capillary permeability.
    • Viable platelets significantly increase pulmonary capillary permeability.
    • Prolonged storage in PVC containers may worsen this effect.
    • Eliminating platelets and buffy coat largely prevents increased capillary permeability.

    Conclusions:

    • Blood transfusion can induce lung injury by increasing pulmonary capillary permeability.
    • Platelets are key mediators of transfusion-related lung injury.
    • Storage conditions and blood component removal impact transfusion safety.