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Updated: Jul 31, 2026
12:14
Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
Published on: February 12, 2016
[Cerebral infarct and the immune response]
1I. neurologická klinika Fakultnej nemocnice a Lekárskej fakulty Univerzity Komenského v Bratislave.
Bratislavske Lekarske Listy
|June 1, 1997
Summary
Cerebral infarction (CI) triggers significant changes in both humoral and cell-mediated immunity, including altered antibody levels and increased immune response indices. Antiphospholipid antibodies (aPLs) are identified as a key risk factor for stroke, particularly in younger individuals.
Area of Science:
- Immunology
- Neurology
- Pathophysiology
Context:
- Limited data exists on the immunological mechanisms underlying cerebral infarction (CI).
- Understanding immune responses in CI is crucial for identifying risk factors and potential therapeutic targets.
Purpose:
- To investigate humoral and cell-mediated immunity in patients with focal brain ischemia (CI).
- To explore the role of antiphospholipid antibodies (aPLs) in stroke occurrence and recurrence.
- To analyze the association of HLA antigens with CI.
Summary:
- Patients with CI exhibited higher antibody levels against a panel of antigens compared to healthy controls, with significant increases in IgA and CSF immunoglobulins.
- Cell-mediated immunity showed increased stimulatory (SI) and immunoregulatory (IRI) indices, particularly in younger stroke patients.
- Anticardiolipin antibodies (aCLs), a type of aPL, were found in 9.8% of first-stroke patients, indicating a significant risk factor, especially for younger individuals and recurrent strokes.
- Genetic factors, suggested by altered HLA antigen frequencies, may also contribute to CI onset.
Impact:
- This study highlights the complex interplay between the immune system and cerebral infarction.
- Identifies aPLs as a significant, potentially causal, risk factor for stroke, guiding future research and clinical management.
- Suggests potential genetic predispositions to CI, warranting further investigation.
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