Related Experiment Video
Updated: Oct 9, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
[Fluoxetine, akathisia and suicide]
C Lançon1, D Bernard, T Bougerol
1Service hospitalo-universitaire de Psychiatrie, CHU Sainte-Marguerite, Marseille.
Abstract:
Several cases of suicidal thinking or suicidal behavior during fluoxetine treatment are described in the literature. Akathisia or dysphoric extrapyramidal reactions may explain the emergence of suicidal ideation during fluoxetine treatment. Retrospective and controlled studies found no relationship between fluoxetine and the emergence of suicidal ideation. Some cases reports of akathisia or suicidal ideation with other selective serotonin reuptake inhibitors (SSRIs) suggest that same mechanisms (pharmacokinetic or pharmacodynamic interactions) are involved in extrapyramidal effects during treatment with SSRIs. The clinical use of SRIs is discussed.
More Related Videos
Related Concept Videos
Antidepressant Drugs: Overview
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Antidepressant Drugs: MAOIs and Other Agents
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
A study on guinea pigs examined the...

