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Sympathetic influence on ventricular compliance

B Coleman, M C Worthen, D M McCanon

    Japanese Heart Journal
    |March 1, 1976
    PubMed
    Summary
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    Extreme sympathetic stimulation, induced by veratrine, significantly reduced left ventricular diastolic compliance in dogs. This effect was reversed by stellectomy, highlighting the role of sympathetic nerves in diastolic function.

    Area of Science:

    • Cardiovascular Physiology
    • Autonomic Nervous System Regulation

    Background:

    • Left ventricular diastolic compliance is crucial for proper cardiac function.
    • The sympathetic nervous system plays a significant role in modulating cardiac performance.

    Purpose of the Study:

    • To investigate the impact of intense sympathetic stimulation on left ventricular diastolic compliance.
    • To compare these effects with volume expansion and sympathetic denervation.

    Main Methods:

    • Intracisternal injections of veratrine in anesthetized dogs to induce sympathetic stimulation.
    • Measurement of left ventricular end-diastolic pressure (LVEDP) and segment length (LVEDC).
    • Assessment of effects following bilateral stellectomy and during volume expansion (transfusion).

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    Main Results:

    • Veratrine administration led to a disproportionate increase in LVEDP compared to LVEDC, indicating reduced diastolic compliance.
    • Bilateral stellectomy reversed the decrease in diastolic compliance.
    • Sympathetic stimulation also increased left ventricular systolic pressure (LVSP) and its first derivative (LV dp/dt).

    Conclusions:

    • Intense sympathetic stimulation significantly impairs left ventricular diastolic compliance.
    • The sympathetic nervous system, particularly via the stellate ganglia, is a key determinant of diastolic function.
    • These findings differentiate the effects of sympathetic stimulation from simple volume expansion on diastolic properties.