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Related Experiment Videos

Anticholinergic poisoning from Jimson weed

D A Mahler

    JACEP
    |June 1, 1976
    PubMed
    Summary

    Jimson weed (Datura stramonium) ingestion causes atropine-like poisoning in adolescents. Physostigmine effectively reverses these dangerous anticholinergic effects, aiding emergency treatment.

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    Area of Science:

    • Toxicology
    • Pharmacology
    • Emergency Medicine

    Background:

    • Jimson weed (Datura stramonium) is a plant containing toxic belladonna alkaloids.
    • Adolescents intentionally ingest Jimson weed for its psychedelic effects.
    • Ingestion leads to atropine-like poisoning with hallucinations and thought disturbances.

    Purpose of the Study:

    • To describe the clinical presentation of Jimson weed intoxication.
    • To highlight diagnostic challenges, including differentiation from LSD ingestion and schizophrenia.
    • To evaluate the efficacy of physostigmine in treating Jimson weed poisoning.

    Main Methods:

    • Clinical case review of patients presenting with Jimson weed ingestion.
    • Recognition of characteristic anticholinergic toxidrome.
    • Assessment of patient response to physostigmine treatment.

    Main Results:

    • Patients exhibit physical signs of atropine-like poisoning.
    • Diagnosis relies on history and anticholinergic effect recognition.
    • Physostigmine successfully reversed both central and peripheral symptoms.

    Conclusions:

    • Jimson weed poisoning presents with a distinct anticholinergic toxidrome.
    • Prompt diagnosis and treatment with physostigmine are crucial for managing toxicity.
    • Understanding this poisoning is vital for emergency department clinicians.

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