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Updated: Aug 4, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Pefloxacin mesylate--clinical effectiveness in various forms of infectious-inflammatory diseases]

V P Pozdniakova, L Ia Nestetrova, L B Smirnova

    Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
    |January 1, 1997
    PubMed

    Insights

    Pefloxacin mesylate, a potent fluoroquinolone antibiotic, demonstrates high efficacy (over 90%) and good tolerance for treating severe and difficult-to-treat infections, including those caused by intracellular pathogens. Its favorable pharmacokinetic profile allows for convenient twice-daily dosing in both inpatient and outpatient settings.

    Area of Science:

    • Pharmacology
    • Infectious Diseases
    • Microbiology

    Background:

    • Pefloxacin mesylate is a broad-spectrum fluoroquinolone antibiotic.
    • It exhibits activity against multidrug-resistant pathogens.
    • Severe and difficult-to-treat infections pose significant therapeutic challenges.

    Purpose of the Study:

    • To evaluate the therapeutic efficacy and pharmacokinetic profile of pefloxacin mesylate.
    • To establish pefloxacin mesylate as a promising drug for severe infections.
    • To highlight its utility against intracellular pathogens.

    Main Methods:

    • Clinical assessment of therapeutic efficacy.
    • Pharmacokinetic studies to determine bioavailability and dosing.
    • In vitro and in vivo studies against various pathogens.

    Main Results:

    • Pefloxacin mesylate demonstrated high therapeutic efficacy, exceeding 90%.
    • The drug exhibited good tolerance in patients.
    • Favorable pharmacokinetics and high bioavailability supported twice-daily administration.
    • It proved effective against intracellular pathogens.

    Conclusions:

    • Pefloxacin mesylate is a highly effective and well-tolerated antibiotic for severe infections.
    • Its pharmacokinetic properties facilitate convenient dosing regimens.
    • It is a drug of choice for infections caused by intracellular pathogens.

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